CAMILO DE LA FUENTE-SANDOVAL
MD, PhD · Instituto Nacional de Neurología y Neurocirugía (INNN)
Mexico City, Mexico
Mexico City, Mexico
Schizophrenia
Neuroimaging
Glutamate
Early Psychosis
Precision Psychiatry
Abstract
Camilo de la Fuente-Sandoval: Glutamate as biomarker of treatment response in early-stage schizophrenia
Dr. Camilo de la Fuente-Sandoval, honored with the Schizophrenia International Research Society’s prestigious 2024 Global Schizophrenia Award, has transformed early psychosis research through groundbreaking neuroimaging studies at Mexico’s Instituto Nacional de Neurología y Neurocirugía (INNN). His pioneering MRI spectroscopy investigations in antipsychotic-naïve individuals experiencing their first episode of psychosis have profoundly influenced our current understanding of the neurochemical alterations linked to psychosis onset and subsequent antipsychotic treatment. His Laboratory of Experimental Psychiatry has become a beacon for innovative schizophrenia research in Latin America, supported by prestigious funding from the U.S. National Institutes of Health, the Secretariat of Science, Humanities, Technology, and Innovation, UC MEXUS-CONACyT, and multiple Mexican scientific agencies. The Genomic Press Interview reveals how this distinguished scientist channeled personal experiences into scientific excellence, establishing comprehensive clinical programs that provide free care while advancing personalized medicine approaches. His seminal discoveries demonstrating elevated glutamate levels in the associative striatum of first-episode psychosis patients, which normalize after effective treatment, have opened new avenues for biomarker development and targeted interventions. Leading international collaborations including the ENIGMA Clinical High Risk for Psychosis Working Group, Dr. de la Fuente-Sandoval bridges translational neuroscience and global mental health, offering unprecedented insights into schizophrenia within resource-limited contexts. His visionary work combining neuroimaging, electrophysiology, cognition, and inflammation markers represents a paradigm shift toward precision psychiatry, inspiring a new generation of researchers across the Global South while fundamentally advancing our understanding of psychosis mechanisms and treatment response prediction.
For more information on Dr. de la Fuente-Sandoval’s life and career, read his  Genomic Press Interview.
Also featured in  El País — world’s largest news provider in Spanish.
To download the infographic on Dr. Camilo de fa Fuente-Sandoval, click here.
CAMILO DE LA FUENTE-SANDOVAL
MD, PhD · INNN · Mexico City, Mexico
Glutamate as biomarker of treatment response in early-stage schizophrenia
2024
GLOBAL
Schizophrenia
Award · SIRS
Award · SIRS
3,358+
Citations
Google Scholar
Google Scholar
73+
Publications
Peer-Reviewed
Peer-Reviewed
8%
First-Episode Patients
with Secondary Causes
with Secondary Causes
22M
Metro Population
Served · Free of Charge
Served · Free of Charge
We walked without looking for each other but knowing that we were walking to find each other.
Camilo de la Fuente-Sandoval · Instituto Nacional de Neurología y Neurocirugía (INNN), Mexico City
01
Glutamate & Early Psychosis
Translational Neuroscience
- Pioneer of MR spectroscopy in first-episode psychosis in Mexico, beginning in 2000
- Discovered elevated glutamate in the associative striatum of antipsychotic-naïve patients
- Demonstrated glutamate normalization following effective antipsychotic treatment
- Elevated striatal glutamate predicts conversion to psychosis in ultra-high-risk individuals
- First to link dopamine-glutamate interaction to early psychosis biomarkers in Latin America
- Findings published in Neuropsychopharmacology, opening new avenues for treatment prediction
02
The INNN Clinical Ecosystem
Clinical Innovation
- Founded Laboratory of Experimental Psychiatry at INNN in 2006
- Established Mexico's only ambulatory urgent-care clinic for early psychosis — free of charge
- Full workup within 24 hours: MRI, glutamate spectroscopy, neuropsychology, inflammation markers
- Treatment initiated same day — unique in Mexico
- Systematic screening identifies ~8% of patients with secondary causes (autoimmune, thyroid, structural)
- Serving a metropolitan area of 22 million with severely limited mental health resources
03
International Collaborations
Global Psychiatry
- Leader in ENIGMA Clinical High Risk for Psychosis Working Group
- NIH-funded research, alongside Mexican agencies and UC MEXUS-CONACyT
- Co-author on landmark meta-analysis of glutamate variability in schizophrenia, Molecular Psychiatry 2023
- Positions Latin America as contributor to global schizophrenia research, not merely recipient
- Research on intracortical myelin and paliperidone palmitate in recent-onset schizophrenia
- Data informing precision psychiatry models applicable to low-resource settings worldwide
04
Science, Exile & Vision
Science & Society
- Born in Chillán, Chile; arrived in Mexico in 1973 as infant refugee from Pinochet coup
- Father was a deputy in Allende's government — scientific career cut short by exile
- Argues "schizophrenia" is an umbrella label for conditions medicine cannot yet separate
- Advocates for differential diagnosis and personalized treatment over trial-and-error antipsychotics
- Featured in El País (September 2025) as revolutionary force in psychosis care in Latin America
- Only Mexican scientist ever to receive the SIRS Global Schizophrenia Award (2024)
Glutamate Pioneer
Exile to Excellence
Free Care Innovator
Global South Science
Precision Psychiatry
Genomic Press Interviews
The Brilliant Minds Behind the Science
Instituto Nacional de Neurología y Neurocirugía · Mexico City, Mexico · 2025
Source: Genomic Press Interview · Brain Medicine · 2025
Source: Genomic Press Interview · Brain Medicine · 2025